Combinatorial Chemistry

^{Columns for Combinatorial Chemistry}

^{Columns for Combinatorial Chemistry}

TLCAdvantage™ HTS

High Speed Screening Column

Gradient:
4ml/min. 0-4 min, 100% A to 100% B. Hold one minute. 5-6 min 100% B to 100% A.

Sample: 1) 1-Hydrox-7-aza-benzotriazole 2)
4-methoxybenzene sulfonamide 3)
Methyl 3-amino-2-thiophenecarboxylate
4) 4-Aminobenzophenone

Precision (RSD):
1) 3.38
2) 0.76
3) 0.50
4) 0.36

* No precautions were taken to inject at precisely the same time in each cycle.

Detection: 220nm

Discussion: The new TLCAdvantage HTS has been designed to equilibrate rapidly at high water content and hold up under the aggressive conditions needed to screen large numbers of compounds characteristic of combinatorial chemistry. The test mixture represents compounds which are difficult to chromatograph. The column exhibits excellent reproducibility with these type of samples under these conditions.

These columns have exhibited good reproducibility even after almost 1,000 samples.

TLCAdvantage HTS, C18, Stainless Steel Columns

4.6 mm ID x L, mm Price

TLC023-4G Guard Cartridges 10 $150/5

TLC023-046050 Analytical 50 210

TLC023-046100 100 225

TLC023-046250 250 290

21.5 mm ID x L, mm Price

TLC023-10G Guard Cartridges 10 $400/5

TLC023-215050 50 750

Guard Cartridges & Holders
x L, mm
Price

100014 Analytical Guard Holder
w/Direct Connect for any column 10 $85

100012 Guard Holder, Integral
for TLCAdvantage column 10
85

Many other chemistries, lengths and ID’s are available. Please inquire.

Information and prices on other TLCAdvantage columns can be obtained by submitting our request form.

TLCAdvantage Silica, 5µm, 60Å

4.6 mm ID x L, mm Price

TLC041-4G Guard Cartridges 10 $150/5

TLC041-046050 Analytical 50 210

TLC041-046100 100 225

TLC041-046250 250 290

21.5 mm ID x L, mm Price

TLC041-10G Guard Cartridges 10 $400/5

TLC041-215050 Preparative 50 625

TLC041-215100 100 830

TLC041-215250 250 1,600

Guard Cartridges & Holders
x L, mm

100014 Analytical Guard Holder with Direct Connect for any column
10
$85

100012 Guard Holder, Integral
for TLCAdvantage column
10
85

100009 Preparative Guard Holder w/Direct Connect for all columns 10mm ID and greater
10
205

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^{Columns for Combinatorial Chemistry}
TLCAdvantage™ HTS
	High Speed Screening Column Gradient: 4ml/min. 0-4 min, 100% A to 100% B. Hold one minute. 5-6 min 100% B to 100% A. Sample: 1) 1-Hydrox-7-aza-benzotriazole 2) 4-methoxybenzene sulfonamide 3) Methyl 3-amino-2-thiophenecarboxylate 4) 4-Aminobenzophenone Precision (RSD): 1) 3.38 2) 0.76 3) 0.50 4) 0.36 * No precautions were taken to inject at precisely the same time in each cycle. Detection: 220nm Discussion: The new TLCAdvantage HTS has been designed to equilibrate rapidly at high water content and hold up under the aggressive conditions needed to screen large numbers of compounds characteristic of combinatorial chemistry. The test mixture represents compounds which are difficult to chromatograph. The column exhibits excellent reproducibility with these type of samples under these conditions.
These columns have exhibited good reproducibility even after almost 1,000 samples.